Abstract: The influence of blasting vibration on the interaction between the rock pile and the embedded rock mass is obvious, which is an important factor affecting the failure of the anti-slide pile. According to the prototype of a landslide in Yueyang, Hunan Province, the dynamic response of anti-slide pile and embedded rock mass with blasting vibration is established by FLAC3D.The results show that under the condition of the width and height of the fixed bedrock and the depth of the anti-slide pile, the displacement, acceleration, velocity and stress of the rock in the embedded rock are in accordance with their homogeneity under the conditions of the elevation amplification effect. However, when the wave impedance difference in the inhomogeneous rock mass is large, the acceleration response does not exactly accord with the elevation amplification effect. The displacement, acceleration and velocity curves of the embedded rock mass in the same horizontal position of the cantilever anti-slide pile are consistent and the stress is inconsistent. The pile at both ends of the moment and the shear force is small, the middle is large, and after the blasting the middle of the landslide and the trailing edge of the landslide are susceptible to torsional failure, it should strengthen the anti-slide pile in the bedrock and sliding body interface and landslide protection of central and trailing edge. Based on the above results, the frequency of the blasting vibration process is analyzed by MATLAB,which can be judged to be safe after blasting. The results provide a scientific basis for the design and construction of landslide.