The calculation result of stability of anisotropic rock slope is directly dependent on the value of shear strength parameters of the rock mass. In order to take the influence of rock anisotropy on slope stability into account, we use CSMR instead of RMR in the H-B strength criterion, and modify the parameters mb and s. Then, the equivalent M-C strength parameters of anisotropic rock mass can be obtained. They are combined with the calculation of the slope engineering at the exit of the diversion tunnel of a hydropower station in Jinsha River. The safety factors of the slope stability before and after the correction of the strength parameters under the same bedrock conditions and different excavation design schemes are calculated and compared. The results indicate that the stability of the slope is greatly affected by the anisotropy of rock mass. Without considering the anisotropy of rock mass, the stability of slope cannot be accurately reflected in the calculation result of slope stability. After anisotropy correction, the calculation results of slope safety factors of the two design schemes are 1.11 and 1.70 respectively, which are basically consistent with the qualitative and semi-quantitative evaluation. In summary, the method for correcting the parameters of anisotropic rock mass of slope is feasible.