Abstract: With the construction of western engineering facilities, the problems of bridge structure diseases in complex geological landslides are often encountered, and the most complicated one is the most unfavorable combination of coupling deep landslide bodies and bridge construction through the sliding surface of landslides, which poses a serious threat to land transportation safety operations. In this paper, the Zaoshugou bridge is paralleled by the old landslide with a thickness of 40m, and the conventional model test is established to simulate the rainfall condition by water injection. The deformation of the bridge pier and anti-slide pile coordination problem under the landslide deformation of this kind of bridge-landslide system exploratory analysis of mechanism and dynamic response. The results of the study show that:(1)The landslide body slides many times, the rock and soil structure is destroyed, the strength is significantly reduced, some landslide bodies are thicker, it is difficult to find a suitable bearing layer, and the original design and treatment plan for the pier played a very good role in protection. (2)The deformation of the sliding body may not be obvious in the case of small deformation, and the stability of the landslide is not significant. The pier is a sensitive structure. The small deformation of the landslide may have a great effect on the pier and even cause the pier to break, thus forming the microscopic progressiveness of the slope-the dynamic response mode of the macroscopic deformation of the pier. (3)The effect of slope deformation on the second row of piles is more obvious, forcing the deformation of the pile top, and the horizontal displacement of x is larger than that of the bridge pier and the first row of piles; the section of the pier is larger than the section of the pile, and the load sharing coordination ratio is renewed. The adjustment is greatly affected by the upper sliding body, so the variation of the pier is more significant than that of the first row. The analysis of the interaction between the bridge and the landslide body is reasonable. The successful treatment of this project can provide constructive reference for similar projects.