Abstract: The control of the seepage field of the water-sealed cavern is important for the construction and operation of the cavern. Grouting treatment of the surrounding rock to derecrease the overall permeability coefficient of the rock around the cave is the most direct and effective engineering treatment. To deal with the excessive discharge water in some sections of the cavern of water-sealed oil cavern during the construction, a method for estimating the overall water inflow of the three-dimensional cavern using numerical calculation results of two-dimensional seepage analysis is proposed. Then, the method is adopted to analyze the amount of water in the cavern under different grouting treatment schemes under the conditions of artificial water curtain. Finally, the optimization measures of grouting at the bottom of the oil cavern are proposed. The results show that the scheme of 5 m-grouting to the whole floor is the best method from the perspective of the effect of reducing discharge water. The target permeability coefficient of the grouting can be adjusted according to the demand of the project for the control of seepage quantity. From the perspective of economy, the scheme of curtain grouting more than 12 m-depth on both sides of the bottom of the cavern can achieve good results. Considering the engineering cost and the effect of reducing the water inflow, the optimization scheme 3 can be selected, that is,the sections of the cavern with a permeability coefficient of 10 Lu have the treatment of the 5 m whole grouting, and the sections with the permeability coefficient of 1 Lu have only curtain grouting on both sides of the bottom, with the depth greater than 12 m. The conclusions of this study can provide a reference for similar projects.