Abstract: Landslide is one of the main factors leading to the failure of pipelines in mountainous areas, with the characteristics of great harm and wide influence. In this paper, we carried out a centrifuge model test of pipeline deformation and failure under landslides and obtained real-time variation curves of soil pressure, pipeline strain, and displacement data. The results are as follows:(1)When the pipeline transversely passes the landslide, the failure mode is overall bending-local buckling and tension deformation at both ends; when the pipeline longitudinally passes the landslide, the failure mode is overall bending-trailing edge tension, slope toe compression, and buckling deformation near the shear outlet. (2)We reveal the interaction mechanism between landslides and pipelines. Due to the different material properties, the pipeline and soil will have stages of coordinated and uncoordinated deformation. (3)Through analyzing pipeline failure models of different pipeline laying ways under the action of landslides. Finally, we concluded that the pipeline had failed before the landslide happened. But when the pipeline longitudinally passes the landslide, the influence of the landslide on pipeline deformation is more hysteretic and smaller than the transverse pipeline. It is suggested that pipeline strain should be used as an indicator for monitoring and early warning. The research results can provide technical support for oil and gas pipeline laying, engineering protection design, monitoring, and early warning.