Abstract: Due to weak purpose and insufficient predictability of slope geological hazard investigation and evaluation, The Slope-geohazard Prevention System of Slope-unit Administrant was introduced to achieve the goal of systematic prevention and control of slope geological hazard risks. Under the premise of fully understanding the disaster-causing conditions, disaster-pregnancy process, and risks of slope hazards, this system advocates that the investigation and prevention of slope geological hazard should be based on different slope units to formulate a warning system, management rules and control measures. In this study, based on the detailed investigation of geological disasters in the key areas of Mayang County, Hunan Province, the basic process, investigation and evaluation methods and index system for the establishment of slope chief system were systematically expounded. Furthermore, we did comprehensive analyses and put forward some recommendations for the following contents: the selection and determination method for key areas; the determination method for slope units and the content for investigation and evaluation; the selection method, standards and responsibility of slope administrant; control process and core content for slope unit, warning model, legal system. The Slope-geohazard Prevention System of Slope-unit Administrant was proposed for the first time. Its establishment and continuous improvement will play a positive role in promoting the improvement of the regional geological hazard prevention and control in China.