Abstract: Taking the moderately collapsible loess foundation in the middle and lower reaches of the Yellow River as the research object, we aim to explore the elimination effect of loess collapsibility during the process of pipe pile driving. The results show that the compaction effect plays a role in changing the physical and mechanical parameters of loess. With the increase in distance from the center point of the pile, the void ratio and dry density of the soil between the piles show a nonlinear increase and decrease trend, respectively, and change significantly within the range of 3 times the diameter. For medium collapsible loess, the collapsibility of loess with a larger burial depth has been completely eliminated, and the collapsibility of loess with shallow burial depth has been completely eliminated or reduced from moderate to slight. Based on the cavity expansion theory, the distance between piles to eliminate collapsibility of loess should not exceed 3 times the diameter, and soil plastic deformation may occur. Further combining the results of in-situ standard penetration and cone penetration tests, it is believed that the bearing capacity of the soil between the piles and single pile has been significantly improved. This provides theoretical and data support for the foundation treatment of collapsible loess in the middle and lower reaches of the Yellow River.