Abstract: The seismic engineering geological conditions of the free field can be changed by soil caves in Karst areas, which affects the results of surface seismic dynamic response. To study the influence of soil caves on ground motion amplification in Karst areas, we used the finite difference method to analyze the seismic response of the site with soil caves under different ground motion input conditions. In this paper, we have several important conclusions as follows:(1)Because the propagation of seismic waves is blocked by soil caves, the peak acceleration at the center of the ground surface is reduced significantly. With the increase of the input ground motion peak, the influence range of the soil caves increases, and the peak acceleration near the soil caves first increases and then decreases, eventually tending toward the free field trend. (2)The vertical displacement of the site is increased by the presence of soil caves. With the increase of peak acceleration input, the vertical displacement also increases gradually. The soil caves have little influence on the horizontal peak displacement. (3)The acceleration amplification coefficient increases first and then decreases, and decreases with the increase of the peak acceleration input. (4)The value of the response spectrum short period is decreased by the presence of soil caves. This reduction is not significantly affected by the peak acceleration input.