Abstract: Taking the slope of longshan substation engineering area as the research object, based on the borehole data and geophysical data, using 3D geological modeling technology and AutoCAD software, the typical geological profile of the slope of substation engineering area was established. The geological profile was imported into the finite element simulation software ABAQUS to obtain the slope numerical model. The stability of slope in engineering area was quantitatively analyzed by strength reduction method. Meanwhile, the influence of different anti-slide pile position on slope stability was studied. The simulation results show that:The plastic strain contour can determine the position of the potential slip plane, and the strength reduction coefficient corresponding to the abrupt displacement point can be used as the slope safety factor. The position of anti-slide pile has a great influence on the potential sliding surface of slope. When anti-slide pile is located in the middle and lower part of the slope, it can effectively prevent the sliding deformation of the upper soil mass, and the lower soil mass will not produce new plastic zone. At this time, the safety factor of slope is the largest, and the effect of anti-slide pile reinforcement is the best. The numerical simulation results can provide important guidance for slope protection design.