Abstract: There are five major engineering problems faced by the deep buried tunnel projects. They include large deformation of soft rock,rock burst,active fault zone,high temperature and humidity,and high slope at the entrance and exit of the tunnel. First,the theory of deep-buried tunnel disaster prevention and control is proposed. It is called the compensation excavation method. The core material called NPR bolt/cable is developed. Then,the prevention and control measures and suggestions for deep-buried tunnels are put forward. They mainly include (1)compensation technology for high pre-tightening force of NPR anchor net and cable for soft rock tunnels,(2)energy absorption compensation technology for rockburst tunnels,(3)double gradient grouting strength compensation technology and (4)NPR anchor-net-cable-truss coupling support technology for active fault zone tunnels,(5) double partition and double control technology for high temperature and high humidity tunnels and (6)NPR anchor cable prevention-reinforcement-monitoring-early warning integrated dual compensation control technology for the high slope at the entrance and exit of the tunnel. Finally,combined with the specific practical engineering experience,the application effect of the prevention and control strategy is explained,in order to providing reference and basis for the construction of the deep buried tunnels.