Abstract: Modern high-tech equipments have more and more strict requests on vibration, in the construction process of a clear workshop, we need to reconstruct parts of non-micro-vibration zone of the workshop into micro-vibration zone for expanding the production lines. In this paper, the finite element model of the clear workshop was established to analysis the micro-vibration problem, which was caused by ground random vibration. The acceleration time series measured on the ground as excitation, the random vibratory response of the workshop structure was analyzed. For three different cases, the vibrations of particular nodes in the structure model were compared, the results indicated that increased pillars could effectively reduce the vibration of the structure, consequently, reasonable proposals for engineering design were put forward.