Abstract: The combination of bridge and slope is usually used to pass through high slopes and valleys in the construction of transportation infrastructure projects, such as highway and railway engineering. And on this occasion, as the factors, such as excavation unloading, rainfall and bridge deck loads, can easily give rise to the destruction of the slope, it cannot be too necessary to pay close attention to the health condition of the slope. In this paper, aiming at high slope-bridge combination engineering under the action of excavation, supporting and bridge deck loads, we chose one typical high slope in the Yunfu-Luoding expressway project, and made a series of 3D finite element numerical simulation by Midas. By studying and analyzing the slope stability and stress distribution in the three stages of initial condition, before supporting, and operation stage, we analyzed the mechanical behaviours and stability of the high slope, and the influence to the bridge made by the slope, as well. The simulation results show that, as the original supporting scheme cannot make an effect on ensuring the slope safety, the stability of high slope decreases remarkably after the excavation, and we have also put forward an improved supporting scheme for the project. And, while the influence to the slope made by the bridge deck loads can be obvious within a limit range, it's insignificant to the overall level. And the change of bridge grade caused by the deformation of the high slope won't make a obvious difference to the driving comfort and safety of the bridge. The study in this paper can guide the construction and maintenance of this slope, and provide reference and ideas to the stability evaluation of the bridge-slope combined engineering in future.