Abstract: Underground water-sealed oil storage caverns are the preferred way to national petroleum reserve because of its advantages in economy, environmental protection, safety, suitability for strategic reserves, and convenience. Construction of the underground water-sealed oil storage caverns is growing rapidly in China. Its construction site selection plays a decisive role in smooth construction and safe operation. This paper selects the east coast of China as the study area. The seismic intensity, active fault, maximum horizontal stress, lithology, groundwater level, average annual rainfall and the distribution of large-scale wharf and oil refinery eight factors are selected as indexes that constitute an evaluation index system of the construction suitability of underground water-sealed oil storage caverns. The system is also based on the analysis of the principle of underground water-sealed oil storage caverns and the location factor. Then, the analytic hierarchy process is applied to determining the weight of each indexes. The space analysis function of ArcGIS is applied to evaluating the suitability of the construction of underground water-sealed oil storage caverns in the study zone. The result of construction suitability evaluation of underground water-sealed oil storage caverns in the east coast of China is obtained in the end. It provides a reference to the scientific site selection of underground water-sealed oil storage caverns in the east coast of China.