Abstract: Jurassic formationand Cretaceous formation are widely distributed in Panxi region. The engineering geological property of red bed is bad and red bed is main sliding-prone stratum. Massive landslides develop in Panxi red bed region, its harm is serious. Large-scale landslides are easy to block rive, induce serious secondary damage. Based on the investigation of large-scale landslide, the paper systemically analyzed failure mode of large-scale landslides and it can supply theoretical support for landslide forecasting and prevention in Panxi red bed region. Through the research, we found that large-scale landslide development is significantly affected by geological structure. The favorable combination of structure planes and primarybedding surfaces lays a foundation for landslide, it controls failure mode of large-scale landslides. According to the characteristic of slope form, this paper divides failure mode of large-scale landslides in Panxi red bed region into three types, namely, consequent sliding, oblique sliding, cuneiform sliding.