Abstract: In high-fill airport engineering, it is important to ground treatment for building airport on karst foundation. The characteristics of airport engineering is analysed, and the hazards of airport engineering in karst is summarized. According to the airport road groove and the influence zone, the investigation of karst foundation detection, surface karst treatment, underground karst treatment, treatment of karst water are proposed principles and measures. In accordance with detailed study of treatment for the airport road groove and the influence zone, excavation rock foundation, excavation cover soil and filling karst foundation treatment are proposed treatment methods and the construction process. Through the application of karst ground treatment for an airport in the southwest, processing method has been proposed, the treatment effect is significant.