Abstract: The influence factors analysis of the slope stability is the important basis for understanding the deformation failure mechanism, evaluating stability and forecasting deformation trend of the slope. For secondary layered structure slope in the slope engineering, first of all, the main cause mechanism of the secondary layered structure rock mass was briefly analyzed; then the important factors that affect this kind of slope stability were selected according to the characteristics of secondary layered structure slope and the engineering experience, and the quantitative results of influence degree of these factors on theslope deformation and destruction were obtained through the orthogonal test of parameter selection and the numerical simulation software UDEC.The results show that: this type of layered structure is a kind secondary structure within the rock mass near the surface, because of the stress releasefrom three aspects including stress differentiation, unloading rebound with the differencesand dynamic load; all of the primary and secondary ordersof the factors effect on the stability of consequent secondary layered structure slope.were not identical; When the single factor change, the slope stability coefficient, maximum open degree of secondary layer and slope top displacement also showed different characteristics. The study results have important theoretical and practical significance for the excavation design and supporting measures of secondary layered structure slope.