Abstract: Considering the horizontal seismic action and the anchor-frame reinforcement, we propose a seismic stability analysis method on the basis of general slice principle for the anchor-frame reinforced slope. The equilibrium of single slice in differential form is analyzed firstly. Then the limit equilibrium equations of sliding body in integral form are deduced. Finally the equations are solved with programming of ergodic searching. Taking the anchor-frame reinforced slope on an expressway as a prototype, both of the proposed analysis method and the numerical simulation method are used to calculate the safety factor of slope under the designed seismic action. The results calculated by these two methods fit each other well, which implies the validity of the proposed method. We also discuss the influences of average anchoring force and seismic action coefficient on the safety factor of seismic stability. The proposed analysis method associated with the general slice principle can provide an efficient means not only for the seismic stability analysis, but also for the preliminary design of anchor-frame reinforced slope.