Abstract: Pressure solution plays an important role in the evolution of rock pores and fractures. The porosity and fissure of rock play a decisive role in CO2 storage and migration. In this paper, based on the multifield coupled numerical simulation program TOUGHREACT-FLAC3D,an additional module considering pressure solution is added. And the theoretical model of one-dimensional laboratory scale is established to explore the effect of pressure solution on CO2 sequestration. This paper is based on pressure-solubilization. The coupling model of limestone THCM is established. The study found that:In the presence of CO2,Pressure solubilization can promote the change of rock porosity, and the effect of pressure solution on porosity is about 20% of the total change of porosity. In mechanics, pressure solution increases the strain rate of rock by about 10%.In terms of mineral evolution, the concentration of calcium increases by about 1/1000,The mineral content is reduced by about 1/1000. The innovation of this paper is on the original coupling calculation module. The calculation module considering pressure solution is added. Based on the previous work, a reasonable and effective simulation experiment is carried out and a quantitative conclusion is drawn.