Abstract: The influence factors of liquefaction resistance of special sand(silt sand, clayey sand and silt sand) in Anqing area were studied by dynamic triaxial test and SEM. The effects of particle size and gradation, particle content and microstructure on sand liquefaction were studied. Research shows:the larger the skeleton particles, the stronger the resistance to liquefaction; the more uniform the particles in the sand, that is,the better the gradation of the soil, the stronger the sand's resistance to liquefaction; with the increase of fine particle mass content, the anti-liquefaction capacity of sand decreases first and then increases, and the corresponding fine particle content content of different types of sands is the weakest. This is mainly due to the different content of fine particles. When the content of fine particles is small, it mainly plays the role of lubrication, which is unfavorable to the liquefaction resistance of sand.