Abstract: Topography is the primary determinant factor of geological route selection. This paper takes Jinsha River Basin of Sichuan-Tibet Railway as the research object. The hypsometric integral, average elevation, relief, average slope and terrain curvature of each sub-catchment are compared and analyzed using geographic information system technology. The entropy weight method is used to evaluate the adaptability of each sub-catchment to geological route selection. So the macro-trend of the line and select the ideal channel can be determined. The results show that the evaluation has a good consistency with field investigations. The channel selection model based on terrain and geomorphological parameters can be applied to similar railway constructions in mountainous areas and have certain theoretical significance and engineering value.