Abstract: Due to Changba Lead-zinc Mine's transition from surface to underground mining in advance,a series of production and safety problems are brought, among which, the stability of slope is the most obvious problem. As result, it is necessary to carry out the stability evaluation and destabilization prediction of slope so as to ensure the safety production of mine. In this paper, firstly, the engineering geology and hydrogeologic condition of mine slope are studied, then, based on the analysis of mine landslide, factors which affect the stability of slope are disclosed, finally, combined with the geological and strata condition of mine district, software named RocLab is adopted to study the rockmass parameters of mine slope,so, mechanical parameters of rock mass of north side and east side of mine are presented,which provide basis for stability evaluation and destabilization prediction of mine slope.