Abstract: The West-East Natural Gas Transportation Pipeline Engineering is famous for the length,variety of geomorphology alone the line and complexity of engineering geological condition. This paper analyzes and evaluates the regional stability according to regional geological conformation, the environment of seismicity, the seism of engineering geological environment and activity of rupture,etc. Along the line dispersed terrestrial saline soil,collapsible loess, expansive soil and soft clay and the potential engineering geological problem are expatiated during construction and management.