Abstract: Because of importance and particularity, it is essential to study the evaluation of seismic safety for underground pipelines between cities. According to the geology material and on-the-spot investigation, seismic activity and seismotectonic environment along the pipeline are comprehensively analyzed and evaluated., and the potential earthquake region is divided. The relative parameters are determined. In the sites along the pipeline, with 10% probability of exceedance in 50 years, the division map of the peak ground acceleration is given. Meantime, geological disaster induced by the earthquake along the pipeline is evaluated. Thus, the seismic fortification parameters and the important basis for disaster prevent and mitigation are provided.