Abstract: The technique of high-resolution seismic reflection profiling was applied to explore sand-stone type uranium deposit in recent years, and seismic facies analysis is crucial and central part for the technique. The theory of seismic facies analysis was introduce firstly in this paper, and the features of seismic facies was analyzed for sand-stone type uranium deposit. Some case studies showed that the technique is feasible and effective to explore sand-stone type uranium deposit.