Abstract: Regional stability analysis has important significance for scientific and rational site selection of underground water sealed caverns. Firstly, this paper puts forward the range of regional stability study area of underground water sealed caverns, around western Pacific coastal area, according to the basic principles of underground water sealed caverns construction site selection and based on fully consideration of the distribution of large-scale Wharf and oil refinery in China. Secondly, the regional faults, formation lithology, peak acceleration of seismic and heat flow values are determined as sensitive factors of regional stability evaluation, based on the analysis of sensitive factors that influence the regional stability of underground water sealed caverns, and taking into account the available data. Then, the sensitive factors are divided into several grades according to the influence on regional stability. Finally, spatial overlay analysis to regional stability of study area is carried out. The results of study area regional stability are obtained, with the method of integrated index and using of MAPGIS.The analysis provides reference and support to location planning of latter large-scale underground water sealed caverns construction in China.