Abstract: Low permeable media are the ideal natural barrier resisting the underground migration of harmful materials. So it becomes the first selected host rock for high-level radioactive waste disposal repository. In review of the hydrogeological research related to the sitting of the disposal repository, the characteristics of geological study of low permeable media are described in the paper. Several problems, such as measurement of geological parameters, groundwater sampling, water flow modeling and geochemical modeling, are presented in detail.