Abstract: Study of dynamics of the regional stability is to reveal the regularities of crustal dynamics, possible engineering hazard effects of the deformation and loss of stability of regional geological body. In this paper, the author systematically put forward a new theory of dynamics of regional stability, which includes basic geological background, the dynamics of regional surface stability, dynamics of regional shallow layer stability, dynamics of reional deep layer stability, dynamics of regional active tectonics, dynamics of regional seismicity, dynamic process and pattern of regional instability, seismic engineering effect in dynamic environment, effect of rock mass in stability, ect.