Abstract: Destruction of frozen soil environment and environmental protection in process of building of Qinghai Xizang Highway are analyzed according to the interaction frozen soil and engineering environment. It is very important to protect the frozen soil enviroment in cold regions for engineering construction. Meanwhile, the effect of human engineering activities on frozen soil and engineering environment is elaborated and a design frame for the monitoring, management, and evaluation of the frozen soil and engineering environent in cold regions is primarily proposed.