Abstract: This paper carrie out deep analysis and research on the regional geological structure, active fault, neotectonic movement characteristics and regional seismic activity of a low and intermediate-level radioactive waste disposal preselected area. And summarizes the basic rules and characteristics to find out that the neotectonic movement and seismic activity are relatively weak. On this basis, this paper carries out the regional crustal stability evaluation. The Low and intermediate-level radioactive waste disposal preselected area belong to relatively stable area. It can meet the requirements of low and intermediate-level radioactive waste disposal site.