Abstract: The Yuxi-Mohan railway, which was an important part of the mid-channel of Trans-Asian railway in the One Belt, One Road initiative, located in the nearby suture zone between Eurasian plate and Indian plate, and in the Mediterranean-Asia geothermal anomaly zone. The geological condition presented the characteristics of three high four active of the Yuxi-Mohan railway. Based on the formatted and distributed features of areal geological hazards, the comprehensive methods of alignment in this mountain region with strong-high intensively seismic were analyzed, and the technology of geological alignment were researched. The conclusions of this paper can also be widely applied in similar geological condition such as the Sichuan-Tibet railway and the Yunnan-Tibet railway.