Abstract: The engineering projects of deep buried tunnels in different positions of tectonic active zone in previous research indicate that the stability of deep tunnels is deeply relevant to in-situ stress. To analyse the influence mechanism of in-situ stress state on rock burst proneness of deep-buried-curved tunnel in Qinghai-Tibet Plateau and its adjacent region,three-dimensional finite element numerical simulation is done to explore the combine action of the angle φ between the maximum horizontal principal stress orientation and tunnel axis,and lateral pressure coefficient K_H on the distribution of strain energy density and rock burst proneness. The results conclude that whenφ is about 45°,the change of φhas the greatest influence on the proneness of rock burst. When the maximum horizontal principal stress orientation is perpendicular to the tunnel axis,the change of K_H has the most significant effect on strain energy density of surrounding rock. When the maximum horizontal principal stress orientation is parallel to the tunnel axis,the change of K_H has the least influence on strain energy density of surrounding rock. The multivariate regression equation is verified by a number of typical deep buried tunnels in the Qinghai-Tibet Plateau and the surrounding area. The multiple regression equation can be applied to quickly evaluate the influence of φ and K_H on tunnel stability serving the tunnel planning and design efficiently.